产品货号：
Z14661
中文名称：
ERK1/2(Phospho-Thr202/Tyr204)抗体
英文名称：
Anti-ERK1/2(Phospho-Thr202/Tyr204)Antibody
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ERK1/2 (Phospho-Thr202/Tyr204) Antibody |
| 指标别名 | MAP kinase 3;MAPK 3;ERK-1;p44-MAPK;MAPK3;ERK1;PRKM3;MAP kinase 1;MAPK 1;ERK-2;p42-MAPK;MAP kinase 2;MAPK 2;MAPK1;ERK2;PRKM1;PRKM2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | MAPK3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Phospho-Erk1/2 (Thr202/Tyr204) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 176-208 amino acids from human Phospho-Erk1/2 (Thr202/Tyr204). |
| 计算分子量 | 43kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade.They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF.Depending on the cellular context,the MAPK/ERK cascade mediates diverse biological functions such as cell growth,adhesion,survival and differentiation through the regulation of transcription,translation,cytoskeletal rearrangements.The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis,mitosis,and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.About 160 substrates have already been discovered for ERKs.Many of these substrates are localized in the nucleus,and seem to participate in the regulation of transcription upon stimulation.However,other substrates are found in the cytosol as well as in other cellular organelles,and those are responsible for processes such as translation,mitosis and apoptosis.Moreover,the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics,including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC);as well as in the fragmentation of the Golgi apparatus during mitosis.The substrates include transcription factors (such as ATF2,BCL6,ELK1,ERF,FOS,HSF4 or SPZ1),cytoskeletal elements (such as CANX,CTTN,GJA1,MAP2,MAPT,PXN,SORBS3 or STMN1),regulators of apoptosis (such as BAD,BTG2,CASP9,DAPK1,IER3,MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2,FRS2 or GRB10).Protein kinases (such as RAF1,RPS6KA1/RSK1,RPS6KA3/RSK2,RPS6KA2/RSK3,RPS6KA6/RSK4,SYK,MKNK1/MNK1,MKNK2/MNK2,RPS6KA5/MSK1,RPS6KA4/MSK2,MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1,DUSP4,DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets,thereby extending the specificity of the cascade. |
| Uniprot ID | P27361 |
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